If any of the following stimulants are likely (by my judgement at resolution time) to, at medicinal doses, have significant, sticky negative cognitive effects, then this market resolves to Yes.
Adderall
Ritalin/Concerta
Vyvanse
Dexedrine
Desoxyn
The bar for "significant" is slightly higher for mood/personality changes than problem solving/executive function/learning speed.
"Sticky" means that it's difficult to reverse the changes even if you stop taking the medication.
@jonsimon Sticky doesn’t have to be permanent. I don’t think o(months) counts though. If it’s o(years) I think that’s obviously sticky. I think if it’s o(months) and quite bad, I might say it’s sticky too.
@EMcNeill I think this doesn’t hit my bar for significant. Maybe I should give a number in dollars to represent “significant.”