Any announcement along the lines of https://blog.google/technology/ai/google-deepmind-isomorphic-alphafold-3-ai-model/ (but for alphafold 4) resolves this market YES.

For example, it may start with:

Introducing AlphaFold 4, [...]

The announcement must be made by Google, Alphabet, Google Deepmind, or a related entity.

If Alphafold 4 hasn't been announced before 2025, resolves NO.

See also:
/Bayesian/will-alphafold-4-be-announced-in-20 (this market)

/Bayesian/will-alphafold-4-be-announced-in-20-47133ddcdde4